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Piperine 95% Black Pepper Extract

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Application Areas

Pharmaceutical Raw Materials

Health Supplement

Product Series

Plant Monomer Series

Product Type

Natural Active Monomer

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  • Product Description
    • Commodity name: Piperine 95% Black Pepper Extract

    I. Basic Product Information

    Project

    Content

    Product Name

    Black pepper extract

    English name

    Piperine

    Source

    The fruit of Piper nigrum L., a plant of the pepper family.

    Active ingredient

    Piperine

    CAS No.:

    94-62-2

    Product Specifications

    95%; 98%

    Detection method

    HPLC

    Product characteristics

    Pale yellow to off-white powder

    Solubility

    Easily soluble in chloroform, ethanol, and diethyl ether; soluble in benzene and acetic acid; almost insoluble in water and petroleum ether.

     

    II. Product Introduction

    1. Source

            Piperine is a substance that... Pepper, a plant of the Piperaceae family Piper nigrum L. of the fruit The high-purity monomeric ingredients, extracted and refined from raw materials, are obtained through processes such as ethanol reflux extraction and purification using macroporous resins, thereby maximizing the preservation of the active ingredients’ structure and efficacy.

    2. Core Efficacy and Applications

    ( 1 ) Enhanced bioavailability: As a classic   “Absorption enhancers,” which can inhibit drug-metabolizing enzymes in the intestine (such as... CYP3A4 ) and P - Glycoprotein activity, reduced drug use Metabolism and efflux of active ingredients in the intestine significantly enhance the intestinal absorption and bioavailability of fat-soluble compounds (such as curcumin, tanshinone, vitamins, and certain drugs).

    ( 2 ) Anti-inflammatory and analgesic: inhibits inflammatory factors ( TNF- Alpha, IL-6IL-1 β) Release, blocking inflammatory signaling pathways; at the same time, by modulating neurotransmitter release and inhibiting pain signal transmission, it alleviates inflammatory pain (such as arthritis pain) and neuropathic pain.

    ( 3 ) Antioxidant stress resistance: Scavenges free radicals in the body and enhances antioxidant enzymes. SOD GSH-Px ) It exhibits activity, reduces oxidative damage, and provides certain protective effects on hepatocytes, neuronal cells, and other cell types.

    ( 4 ) Regulating metabolism and weight management: Promoting fat breakdown, inhibiting adipocyte proliferation and lipid synthesis; improving insulin sensitivity and assisting in the regulation of blood glucose and blood lipid levels (to be used in conjunction with diet and exercise).

    ( 5 ) Antibacterial and antiviral: It inhibits the growth of a variety of bacteria (such as Escherichia coli, Staphylococcus aureus, and Helicobacter pylori); and exhibits a mild inhibitory effect on the replication of certain viruses (such as influenza virus and herpes virus).

    (6) Neuroprotective adjuvant: Improves cerebral microcirculation, inhibits neuronal apoptosis, alleviates neuroinflammation, and provides certain protective effects on cognitive function (especially when combined with ingredients such as curcumin, the effect is even more pronounced).

     

    III. Technical Specifications and Testing Standards

    Testing items

    Testing standards

    Test results

    Detection method

    Specifications

    ≥98.0%

    98.1%

    HPLC

    Characteristics

    Pale yellow to off-white powder

    Pale yellow to off-white powder

    Visual inspection

    Smell

    Unusual odor

    Unusual odor

    Sensory evaluation

    Granularity

    99% passes through an 80-mesh sieve.

    99% passes through an 80-mesh sieve.

    Sift

    Heavy metals

    ≤10 ppm

    <10 ppm

    AAS

    Lead

    ≤2 ppm

    <2 ppm

    AAS

    Arsenic

    ≤2 ppm

    <2 ppm

    AAS

    Moisture

    ≤3.0%

    1.15%

    Constant-temperature drying method

    Ash content

    ≤3.0%

    1.15%

    High-temperature incineration method

    Total colony count

    ≤1000 CFU/g

    30 CFU/g

    Plate Count Method

    Mold yeast

    ≤100 CFU/g

    20 CFU/g

    Plate Count Method

    Escherichia coli

    Not detectable

    Not detectable

    Selective medium method

    Salmonella

    Not detectable

    Not detectable

    Selective enrichment method

     

    IV. Packaging and Storage

    1. Packaging specifications

    ● Small packaging: Sterile aluminum foil pouch (lined with a double-layer polyethylene bag)

    ● Large packaging: 25 kg cardboard drum (lined with double-layer polyethylene bags, drum lid sealed);

    ● Export packaging: Packaging available upon request.

    2. Storage conditions

    ● Storage conditions: Store in a sealed, cool, and dry place (temperature ≤25℃, relative humidity ≤60%), and avoid direct sunlight, high temperatures, and humidity.

    ● Shelf life: 24 months when stored under appropriate conditions and the package remains unopened;

    ● Transportation precautions: Handle with care and avoid crushing or damage; during transportation, protect from sunlight and moisture.

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