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Danshen Extract, Danshensu 10%-98%

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Product Center

Application Areas

Product Series

Salvia Extract Series

Product Type

Standardized Extract

Pharmaceutical Raw Materials

Reference Substance

Natural Active Monomer

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  • Product Description
    • Commodity name: Danshen Extract, Danshensu 10%-98%

    I. Basic Product Information

    Project

    Content

    Product Name

    Danshen extract

    English name

    Salvianolic acid A

    Source

    Salvia miltiorrhiza, a plant of the Lamiaceae family Salvia miltiorrhiza Bge. Dried roots and rhizomes

    Active ingredient

    Danshenone

    CAS No.:

    76822-21-4

    Product Specifications

    98%; 10%

    Detection method

    HPLC

    Product characteristics

    Off-white crystalline powder

    Solubility

    Soluble in methanol, ethanol, DMSO Organic solvents

     

    II. Product Introduction

    1. Source

    Danshenone It is Salvia miltiorrhiza, a plant of the Lamiaceae family. Salvia miltiorrhiza Bge. A highly purified monomeric ingredient is extracted and refined from dried roots and rhizomes using processes such as ethanol reflux extraction and purification with macroporous resin, thereby maximizing the preservation of the active ingredients’ structure and efficacy.

    2. Core efficacy

    ( 1 Cardiovascular protection: dilates coronary arteries, improves myocardial blood supply, inhibits platelet aggregation, and reduces the risk of thrombosis; alleviates myocardial ischemia-reperfusion injury, regulates blood lipids (reduces triglycerides and cholesterol), and improves endothelial function.

    ( 2 Anti-inflammatory and antioxidant: Scavenges free radicals in the body and inhibits inflammatory factors (such as... TNF- Alpha, IL-6 ) Release, alleviate tissue inflammatory responses, and reduce oxidative stress-induced cellular damage.

    ( 3 Neuroprotection: inhibits neuronal apoptosis, improves cerebral blood circulation, and alleviates cerebral ischemia. Hypoxic injury has a protective effect on cellular damage associated with neurodegenerative diseases.

    ( 4 ) Liver and kidney function protection: Reduces the degree of liver fibrosis and inhibits hepatocellular damage; improves microcirculation in renal tissues, alleviates renal inflammation and fibrosis, and protects kidney function.

    ( 5 ) Other auxiliary effects: Mildly inhibits the proliferation and invasion of tumor cells; regulates the activity of immune cells, enhancing the body’s immune function; improves microcirculatory dysfunction.

    3. Core Applications

    ( 1 Cardiovascular diseases: Used as an adjunctive treatment for coronary heart disease, angina pectoris, myocardial infarction, hyperlipidemia, atherosclerosis, and other conditions; often serves as a key component in traditional Chinese medicine compound formulations or preparations (e.g., Danshen Injection, Danshen Polyphenol Acid Salt Injection).

    ( 2 ) Neurological disorders: Adjunctive treatment for ischemic stroke and the recovery phase of cerebral infarction, as well as supportive intervention for neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.

    ( 3 ) Liver and kidney function-related diseases: Used as an adjunctive treatment for liver fibrosis and chronic hepatitis; helps improve renal dysfunction in chronic kidney disease (such as diabetic nephropathy).

    ( 4 ) Other areas: Used for diseases related to microcirculatory disorders (such as Raynaud’s syndrome); employed as an adjunctive anti-inflammatory and antioxidant ingredient in the management of arthritis and chronic inflammation; and used as supportive care following tumor radiotherapy and chemotherapy (to reduce damage and modulate immune function).

    ( 5 Drug development and formulation: As the hallmark active ingredient of the traditional Chinese medicine Danshen, it is used in quality control standards for Chinese medicinal materials. It can be developed into single-compound drugs, nano-formulations, or compound formulations for targeted clinical treatments.

    III. Technical Specifications and Testing Standards

    Testing items

    Testing standards

    Test results

    Detection method

    Specifications

    ≥98.0%

    98.1%

    HPLC

    Characteristics

    Off-white crystalline powder

    Off-white crystalline powder

    Visual inspection

    Smell

    Unusual odor

    Unusual odor

    Sensory evaluation

    Granularity

    99% passes through an 80-mesh sieve.

    99% passes through an 80-mesh sieve.

    Sift

    Heavy metals

    ≤10 ppm

    <10 ppm

    AAS

    Lead

    ≤2 ppm

    <2 ppm

    AAS

    Arsenic

    ≤2 ppm

    <2 ppm

    AAS

    Moisture

    ≤3.0%

    0.85%

    Constant-temperature drying method

    Ash content

    ≤3.0%

    0.82%

    High-temperature incineration method

    Total colony count

    ≤1000 CFU/g

    30 CFU/g

    Plate Count Method

    Mold yeast

    ≤100 CFU/g

    20 CFU/g

    Plate Count Method

    Escherichia coli

    Not detectable

    Not detectable

    Selective medium method

    Salmonella

    Not detectable

    Not detectable

    Selective enrichment method

     

    IV. Packaging and Storage

    1. Packaging specifications

    ● Small packaging: Sterile aluminum foil pouch (lined with a double-layer polyethylene bag)

    ● Large packaging: 25 kg cardboard drum (lined with double-layer polyethylene bags, drum lid sealed);

    ● Export packaging: Packaging available upon request.

    2. Storage conditions

    ● Storage conditions: Store in a sealed, cool, and dry place (temperature ≤25℃, relative humidity ≤60%), and avoid direct sunlight, high temperatures, and humidity.

    ● Shelf life: 24 months when stored under appropriate conditions and the package remains unopened.

    ● Transportation precautions: Handle with care and avoid crushing or damage; during transportation, protect from sunlight and moisture.

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