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Paeoniflorin from White Peony Root Extract: New Research Advances and Application Value in 2025–2026
Release time:
2026-04-30
Recent studies have demonstrated that paeoniflorin exhibits multiple bioactivities, including anti-inflammatory, neuroprotective, and hepatoprotective effects. Advances in high-purity preparation and formulation technologies have further facilitated its application in the functional food and pharmaceutical sectors.
Recent studies have demonstrated that paeoniflorin exhibits multiple bioactivities, including anti-inflammatory, neuroprotective, and hepatoprotective effects. Advances in high-purity preparation and formulation technologies have further facilitated its application in the functional food and pharmaceutical sectors.
White peony (Paeonia lactiflora Pall.) is a classic, high-volume traditional Chinese medicinal material, with paeoniflorin (PF) as its core bioactive constituent. Paeoniflorin is a water-soluble monoterpenoid glycoside, and modern pharmacological studies have demonstrated that it exhibits a wide range of biological activities, including anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, and immunomodulatory effects. During 2025–2026, research teams both domestically and internationally made significant advances in elucidating the mechanisms of action of paeoniflorin and in developing its applications.
Anti-inflammatory and immunomodulatory effects: Paeoniflorin inhibits NLRP3 inflammasome activation, thereby reducing the release of pro-inflammatory cytokines such as IL-1β, TNF-α, and IL-6, and exhibits significant anti-inflammatory activity in gout and arthritis models. Experimental data show that 10 μM paeoniflorin can decrease the release of inflammatory cytokines by macrophages by 42%.
Neuroprotection and Cognitive Enhancement: A team from Shandong University of Traditional Chinese Medicine has demonstrated that paeoniflorin exerts neuroprotective and anti-vascular dementia effects by activating the PI3K/Akt signaling pathway and suppressing excessive microglial activation. Animal studies have shown that administration of 50 mg/kg/day of paeoniflorin significantly improves learning and memory performance in rat models and reduces amyloid-β plaque deposition.
Hepatoprotection and Metabolic Regulation: A new study from Guangdong Pharmaceutical University (2026) demonstrates that paeoniflorin can reduce serum levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) in mice fed a high-fat diet, while increasing high-density lipoprotein cholesterol (HDL-C), thereby significantly ameliorating hepatic steatosis and insulin resistance. A dosage of 60 mg/kg·day can decrease the hepatic steatosis index by 38%.
Upgraded preparation technology: Shaanxi Hanxuan Phytochem Co., Ltd. employs low-temperature ultrasonic extraction, macroporous resin enrichment, and recrystallization to stably produce a white powder with **peony glycoside content ≥98%**, which exhibits excellent water solubility, high purity, and low impurity levels, making it suitable for the development of functional foods, dietary supplements, and pharmaceutical intermediates.
Paeoniflorin powder from white peony extract—Shaanxi Hanxuan Phytochem Co., Ltd. has been committed to the full-chain production of paeoniflorin extraction and purification. We have long provided stable supplies of 10% paeoniflorin, 50% paeoniflorin, 80% paeoniflorin, 90% paeoniflorin, 95% paeoniflorin, and 98% paeoniflorin, with the high-content single-component paeoniflorin at 95% and 98% consistently occupying the market position for high-content products and maintained in ample stock.
Currently, paeoniflorin is accelerating its transition from a traditional Chinese medicinal ingredient to a modern functional bioactive compound and drug candidate, with its multi-target, low-toxicity profile holding great promise for the prevention and treatment of chronic inflammation, neurodegenerative diseases, and metabolic syndrome.
Keywords： White Peony Extract,Paeoniflorin,Paeoniflorin,Paeoniflorin for Sensitive Skin,Paeoniflorin
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